Chaperone activity studies in living C. elegans

About the topic:

Most biomolecules function inside the cell. However, biochemical assays and analytical tools are mainly applied in vitro, in aqueous buffer solutions or crystals. Our research aim is to discover novel biochemical function by studying biomolecular reactions directly in cells under health and disease conditions. To analyze biomolecular reactions in vivo with high spatio-temporal resolution, we developed novel in-cell spectroscopic and microscopic techniques that range from temperature-induced relaxation to single molecule spectroscopy. We apply the methods in solvent environments of increasing complexity ranging from cytomimetic media and bacteria to (neuronal) cells and multicellular organisms. We currently investigate chaperone activity in C. elegans; for this project we need a team player to implement the analysis of in-cell folding data. 

What they are looking for in students:

From the applicant we would expect a high motivation to engage in the development of an instrument that can explore unresolved and urging questions in life sciences. A basic knowledge and interest in Python programming is required.

Visit the website!

Paper related to the topic