Angew. Chem.: DNA G-quadruplexes play important roles in biological processes and have been identified as promising drug targets, e.g. in anticancer research. In an interdisciplinary collaboration between the laboratories of Prof. Guido Clever and Jun.-Prof. Müge Kasanmascheff, both at TU Dortmund University, a method for the precise distance measurement in pairs of G-quadruplexes with or…
Angew. Chem.: Carboanhydrase hCAII has found its way into the textbooks of drug discovery as a drug target with a particularly rigid active pocket. With the help of detailed NMR spectroscopic analysis, the group of Prof. Dr. Rasmus Linser has now been able to show that this picture needs to be revised, which advises caution when interpreting classical structural data for estimating the "dynamic…
PNAS: A small but important step towards a successful immune reaction is performed by an impressive nanomachine. Researchers use simulations to understand how it works.
Angew.Chem.: Bacterial enzymes are often powerful but also very sensitive catalysts. To call up their performance, they therefore need a special environment.
PNAS: In hydrogenase enzymes, the transports of protons and electrons have been considered to be separate events until now. However, coupling is the key to success here.
'Chemistry - A European Journal' asked 3 questions to solvation scientists Elsa Sanchez-Garcia (University of Duisburg-Essen) and Wolfram Sander (RUB) about their new research on heavy-atom tunneling, which was featured with a cover picture in the journal.